Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.66 |
| ▸ | HTR1B | P28222 | 8/20 | 0.66 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972719 | 0.91 | HTR1D (0.57) | HTR1DHTR1BHTR1AHTR7DRD3 | |
| SCHEMBL8317195 | 0.90 | HTR1D (0.59) | HTR1DHTR1BDRD3DRD2 | |
| SCHEMBL10981096 | 0.84 | HTR1D (0.48) | HTR1DHTR1BHTR1AHTR7DRD3 | |
| SCHEMBL7443673 | 0.82 | DRD2 (0.59) | HTR1DHTR1BHTR1AHTR7DRD3 | |
| SCHEMBL8887147 | 0.78 | HTR1D (0.54) | HTR1DHTR1BHTR1ADRD3DRD2 | |
| SCHEMBL7439769 | 0.75 | FYN (0.56) | HTR1DHTR1BHTR1ADRD3DRD2 | |
| SCHEMBL8132500 | 0.74 | DRD2 (0.54) | HTR1DHTR1BHTR1AHTR7DRD3 | |
| SCHEMBL7437506 | 0.73 | DRD2 (0.53) | HTR1ADRD3DRD2CYP1A2TSHR | |
| SCHEMBL7437526 | 0.73 | DRD2 (0.53) | HTR1ADRD3DRD2CYP1A2TSHR | |
| SCHEMBL7437514 | 0.73 | DRD2 (0.53) | HTR1ADRD3DRD2CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0055043-B1 | 6,7,8,9-TETRAHYDRO-3H-BENZ(E)INDOLAMINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND INTERMEDIATES USED THEREIN, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE INDOLAMINE DERIVATIVES | AYERST, MCKENNA AND HARRISON INC. (CA) | 1985-01-23 | — | — | EP | disclosed |
| EP-0055043-A2 | 6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-06-30 | — | — | EP | disclosed |