Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.59 |
| ▸ | DRD1 | P21728 | 6/20 | 0.59 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HTR1D | P28221 | 3/20 | 0.55 |
| ▸ | HTR1B | P28222 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10972719 | 0.91 | HTR1D (0.57) | DRD2DRD1DRD3DRD4HTR1D | |
| SCHEMBL8317195 | 0.83 | HTR1D (0.59) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL8887664 | 0.82 | HTR1D (0.66) | DRD2DRD3CYP1A2CYP2D6TSHR | |
| SCHEMBL7443670 | 0.80 | DRD2 (0.49) | DRD2DRD1DRD3DRD4CYP1A2 | |
| SCHEMBL7443661 | 0.80 | DRD2 (0.49) | DRD2DRD1DRD3DRD4CYP1A2 | |
| SCHEMBL7436234 | 0.76 | HTR1D (0.86) | DRD2DRD1DRD3DRD4CYP1A2 | |
| SCHEMBL7382314 | 0.75 | DRD2 (1.00) | DRD2DRD1DRD3DRD4CYP1A2 | |
| SCHEMBL30350387 | 0.75 | DRD2 (1.00) | DRD2DRD1DRD3DRD4CYP1A2 | |
| Hydrochloric Acid SCHEMBL29496530 | 0.74 | DRD2 (1.00) | DRD2DRD1DRD3DRD4CYP1A2 | |
| Hydrochloric Acid SCHEMBL7327809 | 0.74 | DRD2 (0.76) | DRD2DRD1DRD3DRD4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |