Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.35 |
| ▸ | XIAP | P98170 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11187956 | 0.88 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11225268 | 0.87 | S1PR1 (0.39) | S1PR1XIAPGRIN1GRIN2B | |
| SCHEMBL10976470 | 0.87 | HTR1A (0.30) | — | |
| SCHEMBL11183533 | 0.83 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11491168 | 0.78 | RIPK1 (0.36) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10977551 | 0.77 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL11186545 | 0.77 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10473627 | 0.76 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10473300 | 0.76 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL10474087 | 0.76 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045171-B1 | 9-AMINO-1-HYDROXYOCTAHYDROBENZO(C)QUINOLINES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 1985-02-13 | — | — | EP | disclosed |
| US-4351833-A | 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof as analgesics and anti-emetics | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| EP-0045171-A2 | 9-Amino-1-hydroxyoctahydrobenzo(c)quinolines and derivatives thereof | PFIZER INC. (US) | 1982-02-03 | — | — | EP | disclosed |
| US-4309545-A | ANALGESICS, TRANQUILIZERS, ANTIEMETICS, DIURETICS, ANTICONVULSANTS, ANTIDIARRHEAL, ANTITUSSIVES AND IN THE TREATMENT OF GLAUCOMA | PFIZER INC. (US) | 1982-01-05 | — | — | US | disclosed |