Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.55 |
| ▸ | HTR3B | O95264 | 2/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.55 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CETP | P11597 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP4 | P49662 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11161534 | 0.98 | KMT2A (0.58) | KMT2APOLBATMALDH1A1HPGD | |
| SCHEMBL11215614 | 0.81 | HTR3E (0.58) | KMT2AHTR3EHTR3BADRB1HTR3A | |
| SCHEMBL11395185 | 0.81 | HRH1 (0.52) | KMT2APOLBATMALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL11217986 | 0.79 | HTR3A (0.56) | KMT2AALDH1A1HTR3EHTR3BADRB1 | |
| SCHEMBL9069333 | 0.79 | HTR7 (0.59) | KMT2APOLBATMALDH1A1HPGD | |
| SCHEMBL2225874 | 0.78 | KMT2A (0.57) | KMT2APOLBATMALDH1A1HPGD | |
| SCHEMBL4816380 | 0.78 | KMT2A (0.64) | KMT2APOLBATMALDH1A1HPGD | |
| SCHEMBL1229731 | 0.78 | HRH1 (0.85) | KMT2APOLBALDH1A1HPGDHTR3E | |
| SCHEMBL11393334 | 0.78 | MAPT (0.62) | KMT2APOLBALDH1A1HPGDHTR3E | |
| SCHEMBL11392536 | 0.77 | CTSS (0.54) | ALDH1A1HTR3EHTR3BADRB1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033660-A1 | 2-(1-Piperazinyl)-cycloheptimidazole derivatives, processes for their preparation, pharmaceutical compositions containing them, and the preparation of such compositions | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-08-12 | — | — | EP | claimed |
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | claimed |
| JP-60260516-A | — | — | None | — | — | JP | disclosed |
| JP-56125384-A | — | — | None | — | — | JP | disclosed |
| JP-S60260516-A | PSYCHOTROPIC AGENT | MITSUI PETROCHEM IND LTD | 1985-12-23 | — | — | JP | disclosed |
| US-4375470-A | 2(1-Piperazinyl)-cycloheptimidazole antihypertensive composition and methods | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-03-01 | — | — | US | disclosed |
| US-4375470-A | 2(1-Piperazinyl)-cycloheptimidazole antihypertensive composition and methods | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-03-01 | — | — | US | disclosed |
| US-4375470-A | 2(1-Piperazinyl)-cycloheptimidazole antihypertensive composition and methods | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-03-01 | — | — | US | disclosed |
| US-4351832-A | 2-(Piperazinyl)-4-pyrimidinamines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-28 | — | — | US | disclosed |
| US-4333937-A | 2-(Piperazinyl)-4-pyrimioinamines | AMERICAN HOME PRODUCTS CORP. (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0039190-A1 | 2-(1-Piperazinyl)-4-pyrimidinamines and related compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-04 | — | — | EP | disclosed |
| WO-1981003022-A1 | 2-(1-PIPERAZINYL)-4-PYRIMIDINAMINES | AMERICAN HOME PROD (US) | 1981-10-29 | — | — | WO | disclosed |
| EP-0056027-A1 | 2-(1-PIPERAZINYL)-4-PYRIMIDINAMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-10-29 | — | — | EP | disclosed |
| JP-S56125384-A | 2-(1-PIPERAZINYL)CYCLOHEPTIMIDAZOLE DERIVATIVE | AMERICAN HOME PROD | 1981-10-01 | — | — | JP | disclosed |
| EP-0033660-A1 | 2-(1-Piperazinyl)-cycloheptimidazole derivatives, processes for their preparation, pharmaceutical compositions containing them, and the preparation of such compositions | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-08-12 | — | — | EP | disclosed |
| EP-0033660-A1 | 2-(1-Piperazinyl)-cycloheptimidazole derivatives, processes for their preparation, pharmaceutical compositions containing them, and the preparation of such compositions | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-08-12 | — | — | EP | disclosed |
| EP-0033660-A1 | 2-(1-Piperazinyl)-cycloheptimidazole derivatives, processes for their preparation, pharmaceutical compositions containing them, and the preparation of such compositions | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-08-12 | — | — | EP | disclosed |
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | disclosed |
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | disclosed |
| US-4258188-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-24 | — | — | US | disclosed |