Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 5/20 | 0.40 |
| ▸ | LDHA | P00338 | 2/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14984199 | 0.82 | INSR (0.65) | INSRMAPTALDH1A1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL11515203 | 0.81 | INSR (0.40) | INSRMEN1KMT2ASMN1; SMN2ADRB2 | |
| SCHEMBL10973513 | 0.77 | TSHR (0.40) | INSRMAPTALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL11516284 | 0.77 | INSR (0.64) | INSRMAPTRAB9ANPC1KDM4E | |
| Hydrochloric Acid SCHEMBL11516293 | 0.77 | INSR (0.64) | INSRMAPTRAB9ANPC1KDM4E | |
| Hydrochloric Acid SCHEMBL11515186 | 0.76 | INSR (0.59) | INSRMAPTRAB9ANPC1MEN1 | |
| SCHEMBL11515408 | 0.75 | LDHA (0.51) | LDHAPSMB8MAPTALDH1A1RAB9A | |
| SCHEMBL13646920 | 0.74 | KMT2A (0.51) | INSRMAPTALDH1A1RAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL11516423 | 0.73 | INSR (0.60) | INSRMAPTRAB9ANPC1MEN1 | |
| SCHEMBL30924931 | 0.72 | LDHA (0.45) | LDHAPSMB8MAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4145537-A | BENZOTHIAZOLIUM DYES | BAYER AKTIENGESELLSCHAFT (DE) | 1979-03-20 | — | — | US | disclosed |