Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20408407 | 0.86 | ACE (0.46) | ACEMETAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9906423 | 0.85 | ACE (0.43) | ACEMETAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31513086 | 0.80 | SIGMAR1 (0.40) | ACEMETAP2POLBCYP1A2CYP3A4 | |
| SCHEMBL16181502 | 0.79 | TRPA1 (0.46) | ACEMETAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24180375 | 0.78 | MAPT (0.39) | ACEMETAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9678878 | 0.78 | PPARG (0.40) | ACEMETAP2POLBCYP1A2CYP3A4 | |
| SCHEMBL9906029 | 0.78 | ACE (0.46) | ACEMETAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24939916 | 0.77 | RIPK1 (0.40) | ACEMETAP2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6991605 | 0.75 | CYP2C19 (0.51) | ACEMETAP2CYP2C19 | |
| SCHEMBL9217462 | 0.75 | ACE (0.44) | ACEMETAP2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4536391-A | REACTING A PLASMIN HEAVY CHAIN WITH UROKINASE IN THE PRESENCE OF A COUPLING AGENT | OTSUKA PHARMACEUTICAL CO. (JP) | 1985-08-20 | — | — | US | disclosed |
| EP-0109653-A2 | Process for preparing urokinase complex | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-05-30 | — | — | EP | disclosed |