Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977153 | 1.00 | DRD2 (0.42) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL10979581 | 0.85 | KMT2A (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4NISCH | |
| SCHEMBL10979584 | 0.85 | KMT2A (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4NISCH | |
| SCHEMBL10759336 | 0.78 | CHRNB4 (0.46) | DRD2DRD1DRD4DRD3CHRNB4 | |
| SCHEMBL10975272 | 0.78 | CHRNB4 (0.46) | DRD2DRD1DRD4DRD3CHRNB4 | |
| SCHEMBL10975275 | 0.78 | CHRNB4 (0.46) | DRD2DRD1DRD4DRD3CHRNB4 | |
| SCHEMBL10980746 | 0.74 | SIGMAR1 (0.55) | DRD2DRD3SIGMAR1 | |
| SCHEMBL10977385 | 0.74 | OPRM1 (0.47) | CHRNB4CHRNA3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL10977382 | 0.74 | OPRM1 (0.47) | CHRNB4CHRNA3SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL10979574 | 0.74 | SIGMAR1 (0.55) | DRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4496579-A | AMINATION WITH AMMONIA OR PRIMARY AMINE; ANTIDEPRESANT | GLAXO GROUP LIMITED (GB) | 1985-01-29 | — | — | US | disclosed |