SCHEMBL10979488

SCHEMBL10979488

FC(F)C(F)(F)Oc1ccccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.40
CETP P11597 2/20 0.40
LMNA P02545 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
AR P10275 1/20 0.36
TSHR P16473 2/20 0.36
SLC6A4 P31645 3/20 0.36
SLC6A2 P23975 2/20 0.36
SLC6A3 Q01959 2/20 0.36
MAPT P10636 2/20 0.36
MEN1 O00255 2/20 0.36
HTT P42858 2/20 0.36
KDM4E B2RXH2 1/20 0.36
PTBP1 P26599 1/20 0.36
MAPK1 P28482 1/20 0.35
HPGD P15428 1/20 0.34
ALDH1A1 P00352 4/20 0.34
USP2 O75604 1/20 0.33
P2RX7 Q99572 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7751907 0.88 ALDH1A1 (0.41) KMT2ACETPLMNASMN1; SMN2AR
SCHEMBL7750622 0.88 LMNA (0.38) KMT2ACETPLMNASMN1; SMN2AR
SCHEMBL30881973 0.84 TSHR (0.39) KMT2ACETPLMNASMN1; SMN2TSHR
SCHEMBL2164875 0.84 TSHR (0.39) KMT2ACETPLMNASMN1; SMN2TSHR
SCHEMBL4122925 0.80 KMT2A (0.43) KMT2ALMNASMN1; SMN2ARTSHR
SCHEMBL10886037 0.78 KMT2A (0.42) KMT2ALMNASMN1; SMN2ARTSHR
SCHEMBL7524628 0.77 TSHR (0.39) KMT2ALMNASMN1; SMN2TSHRMAPT
SCHEMBL14388549 0.77 TSHR (0.36) KMT2ALMNASMN1; SMN2TSHRMAPT
SCHEMBL7928193 0.77 KMT2A (0.41) KMT2ALMNASMN1; SMN2ARTSHR
SCHEMBL10639515 0.75 KMT2A (0.40) KMT2ALMNASMN1; SMN2ARTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0070464-B1 SUBSTITUTED PHENYLCYCLOPROPANECARBOXYLIC-ACID ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS INSECTICIDES BAYER AG (DE) 1985-10-02 EP disclosed