Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | REN | P00797 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10893585 | 0.81 | ACE (0.58) | ACEACE2L3MBTL1LMNAREN | |
| SCHEMBL10893581 | 0.81 | ACE (0.58) | ACEACE2L3MBTL1LMNAREN | |
| SCHEMBL9705353 | 0.80 | ACE (0.61) | ACEACE2L3MBTL1LMNAREN | |
| SCHEMBL9705358 | 0.80 | ACE (0.61) | ACEACE2L3MBTL1LMNAREN | |
| Ethanesulfonic Acid Amide SCHEMBL10976696 | 0.80 | ACE (0.48) | ACEACE2LMNARENKDM4E | |
| SCHEMBL17348400 | 0.79 | FKBP1A (0.45) | ACEACE2HRH1 | |
| SCHEMBL7324427 | 0.78 | ACE (0.57) | ACEACE2L3MBTL1 | |
| SCHEMBL10656762 | 0.78 | ACE (0.53) | ACEACE2LMNARENKDM4E | |
| SCHEMBL18630162 | 0.77 | PREP (0.63) | ACEACE2LMNA | |
| SCHEMBL12600481 | 0.77 | ACE (0.55) | ACEACE2LMNARENKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4533656-A | PYRROLE OR PYRIDINE CARBONYLSULFONAMIDES FOR TREATMENT OF HYPERTENSION OR CONJESTIVE HEART FAILURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-08-06 | — | — | US | disclosed |
| EP-0099709-A2 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-02-01 | — | — | EP | disclosed |