Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.57 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.57 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.48 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9705358 | 0.85 | ACE (0.61) | ACEACE2L3MBTL1 | |
| SCHEMBL9705353 | 0.85 | ACE (0.61) | ACEACE2L3MBTL1 | |
| SCHEMBL10419941 | 0.85 | ELANE (0.47) | ACEACE2DPP4DPP8 | |
| SCHEMBL10419943 | 0.85 | ELANE (0.47) | ACEACE2DPP4DPP8 | |
| SCHEMBL7286797 | 0.83 | ITGB3 (0.60) | ACE | |
| SCHEMBL9041411 | 0.83 | ITGB3 (0.60) | ACE | |
| SCHEMBL4955191 | 0.81 | DPP8 (0.71) | ACEACE2DPP4DPP8DPP7 | |
| SCHEMBL9040814 | 0.81 | DPP8 (0.71) | ACEACE2DPP4DPP8DPP7 | |
| SCHEMBL29363178 | 0.80 | ACE (0.59) | ACE | |
| SCHEMBL11197544 | 0.80 | ACE (0.61) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279750-B1 | AMINOACID DERIVATIVES AS ANTIHYPERTENSIVES | Asahi Breweries, Ltd. (JP) | 1993-01-20 | — | — | EP | disclosed |
| US-4897483-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | ASAHI BREWERIES LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| EP-0279750-A2 | Aminoacid derivatives as antihypertensives | Asahi Breweries, Ltd. (JP) | 1988-08-24 | — | — | EP | disclosed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |