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SCHEMBL1098446

SCHEMBL1098446

O=S(=O)(c1cccnc1)N(Cc1ccc(F)c(F)c1)c1sc2ccccc2c1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 6/20 0.44
▸ NR1D1 P20393 1/20 0.39
▸ NR1H3 Q13133 1/20 0.39
▸ CYP11B1 P15538 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ RORC P51449 1/20 0.35
▸ PKM P14618 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ KMT2A Q03164 2/20 0.34
▸ PTGER2 P43116 2/20 0.34
▸ TP53 P04637 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ TAS2R14 Q9NYV8 1/20 0.34
▸ DPP4 P27487 1/20 0.34
▸ DPP9 Q86TI2 1/20 0.34
▸ DPP7 Q9UHL4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1097497 0.90 TRPM8 (0.57) TRPM8RORC
SCHEMBL1100218 0.90 TRPM8 (0.57) TRPM8CYP11B1LMNAHTTNPSR1
SCHEMBL11886148 0.89 NR1D1 (0.37) TRPM8NR1D1NR1H3CYP11B1LMNA
SCHEMBL1100138 0.89 TRPM8 (0.53) TRPM8HTTPKMKMT2AMEN1
SCHEMBL1098802 0.89 TRPM8 (0.56) TRPM8NR1D1NR1H3CYP11B1LMNA
SCHEMBL1099413 0.87 CYP11B1 (0.43) CYP11B1
SCHEMBL1099636 0.86 DPP4 (0.37) TRPM8NR1D1NR1H3LMNAHTT
SCHEMBL1099403 0.85 TRPM8 (0.46) TRPM8LMNAKMT2AMEN1L3MBTL1
SCHEMBL1098774 0.83 KMT2A (0.44) CYP11B1LMNAHTTNPSR1CYP3A4
SCHEMBL1098734 0.83 TRPM8 (0.56) TRPM8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9434711-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, N.V. (BE) 2016-09-06 — — US disclosed
US-20140315899-A1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-10-23 — — US disclosed
US-8809327-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2014-08-19 — — US disclosed
EP-2183239-B1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2012-08-22 — — EP disclosed
US-20120190674-A1 SULFONAMIDES AS TRPM8 MODULATORS BRANUM SHAWN T (US) 2012-07-26 — — US disclosed
US-8153682-B2 Sulfonamides as TRPM8 modulators JANSSEN PHARMACEUTICA, NV (BE) 2012-04-10 — — US disclosed
US-20090264474-A1 SULFONAMIDES AS TRPM8 MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2009-10-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190674-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885NR1D1 769/4885NR1H3 1207/4885
US-20140315899-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885NR1D1 769/4885NR1H3 1207/4885
US-20090264474-A1 SULFONAMIDES AS TRPM8 MODULATORS TRPM8, TRPM5, TRPM2 TRPM8 1/4885NR1D1 769/4885NR1H3 1207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.