Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.48 |
| ▸ | EGFR | P00533 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 4/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097281 | 0.91 | PDGFRB (0.56) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL1098608 | 0.91 | PDGFRB (0.41) | METEGFRPDGFRBFLT3KDR | |
| SCHEMBL1099325 | 0.87 | PDGFRB (0.52) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL1098224 | 0.86 | PDGFRB (0.56) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL1098299 | 0.85 | PDGFRB (0.61) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL1099698 | 0.85 | PDGFRB (0.48) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL2177690 | 0.82 | MET (0.53) | METPDGFRBFLT3KDRFLT4 | |
| SCHEMBL4523455 | 0.82 | PDGFRB (0.58) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL4524143 | 0.79 | PDGFRB (0.59) | PDGFRBFLT3KDRFLT4CSF1R | |
| SCHEMBL4524623 | 0.78 | PDGFRB (0.57) | PDGFRBFLT3KDRFLT4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | US | disclosed |
| US-8153643-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2012-04-10 | — | — | US | disclosed |
| EP-1802591-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-01-11 | — | — | EP | disclosed |
| US-20090233924-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233924-A1 | Quinazoline derivatives | AQP1, PGF, F12 | MET 1950/4885EGFR 1629/4885PDGFRB 700/4885 |
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | AQP1, F12, AQP3 | MET 2258/4885EGFR 1920/4885PDGFRB 1056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.