Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 5/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | FLT4 | P35916 | 4/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | CDK11B | P21127 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1099234 | 0.93 | TRPA1 (0.65) | TRPA1METKDRFLT3PDGFRB | |
| SCHEMBL1099574 | 0.89 | KDM1A (0.53) | TRPA1METKDRFLT3PDGFRB | |
| SCHEMBL1099781 | 0.87 | PDGFRB (0.59) | KDRFLT3PDGFRBFLT4CSF1R | |
| SCHEMBL1098029 | 0.82 | TRPA1 (0.46) | TRPA1METKDRFLT3PDGFRB | |
| SCHEMBL1098381 | 0.81 | FLT3 (0.72) | TRPA1METKDRFLT3PDGFRB | |
| SCHEMBL1098245 | 0.79 | KDM1A (0.60) | KDRFLT3PDGFRBFLT4CSF1R | |
| SCHEMBL1097832 | 0.79 | PDGFRB (0.67) | KDRFLT3PDGFRBFLT4CSF1R | |
| SCHEMBL1099033 | 0.77 | PDGFRB (0.62) | KDRFLT3PDGFRBFLT4CSF1R | |
| SCHEMBL23158543 | 0.76 | TRPA1 (0.58) | TRPA1METKDRFLT3EGFR | |
| SCHEMBL1098319 | 0.76 | KDM1A (0.63) | KDRFLT3PDGFRBFLT4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | US | disclosed |
| US-8153643-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2012-04-10 | — | — | US | disclosed |
| EP-1802591-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2012-01-11 | — | — | EP | disclosed |
| US-20090233924-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-1802591-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040520-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233924-A1 | Quinazoline derivatives | AQP1, PGF, F12 | TRPA1 3713/4885MET 1950/4885KDR 27/4885 |
| US-20120165351-A1 | QUINAZOLINE DERIVATIVES | AQP1, F12, AQP3 | TRPA1 3413/4885MET 2258/4885KDR 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.