SCHEMBL1099261

SCHEMBL1099261

COC(=O)CCC(NC(=O)C(NC(=O)OC(C)C)C(C)C)c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 13/20 0.42
LMNA P02545 2/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.38
KMT2A Q03164 2/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30419756 0.89 KMT2A (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL31452421 0.89 KMT2A (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL167441 0.89 KMT2A (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL1138368 0.89 KMT2A (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL10268155 0.89 KMT2A (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL3674127 0.89 KMT2A (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL4000328 0.85 MAPK1 (0.42) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL3963100 0.83 KMT2A (0.53) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL336943 0.83 KMT2A (0.53) UTS2RLMNAMAPK1HTTKMT2A
SCHEMBL3001125 0.83 KMT2A (0.53) UTS2RLMNAMAPK1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8153819-B2 Fungicidal mixtures comprising substituted 1-methylpyrazol-4-ylcarboxanilides BASF SE (DE) 2012-04-10 US disclosed
US-20100093738-A1 Fungicidal Compounds and Fungicidal Compositions BASF SE (DE) 2010-04-15 US disclosed
US-7598206-B2 Fungicidal mixtures BASF AKTIENGESELLSCHAFT (DE) 2009-10-06 US disclosed
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-09-24 US disclosed
US-20090233795-A1 Fungicidal Mixtres Based On 3-Monosubstituted N-Bipenyl-Pyrazolecarboxamides BASF AKITENGESELLSCHAFT (DE) 2009-09-17 US disclosed
US-20090203523-A1 Fungicidal Mixtures Made From 1-Methylpyrazol-4-Ylcarboxanilides BASF AKTIENGESSELLSCHFT (DE) 2009-08-13 US disclosed
US-20090131462-A1 Fungicidally Active Agent BASF AKTIENGESELLSCHAFT (DE) 2009-05-21 US disclosed
US-20090123561-A1 Fungicide mixtures based on 1-methyl-pyrazol-4-ylcarboxanilides BASF AKTIENGESELLLSCHAFT (DE) 2009-05-14 US disclosed
US-20090042724-A1 Fungicidal mixtures based on 2,4-disubstituted n-biphenylpyrazolecarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-02-12 US disclosed
US-20090042725-A1 Fungicidal Mixtures Based on 3,5-Disubstituted N-Biphenyl-Pyrazolcarboxamides BASF AKTIENGESELLSCHAFT (DE) 2009-02-12 US disclosed
US-20080293798-A1 Fungicidal Mixtures Comprising Substituted 1-Methylpyrazol-4-Ylcarboxanilides BASF AKTIENGELSELLSCHAFT (DE) 2008-11-27 US disclosed
US-20080255107-A1 Fungicidal Mixtures Comprising N-[2-(Haloalk(Enyl)Oxy)Phenyl]Carboxamides BASF SE (DE) 2008-10-16 US disclosed
US-20080153701-A1 Fungicidal Mixtures BASF AKTIENGESELLSCHAFT (DE) 2008-06-26 US disclosed
US-20080076747-A1 Fungicidal Mixtures BASF AKTIENGESELLSCHAFT (DE) 2008-03-27 US disclosed
US-20080045414-A1 Of 2,3-dimethyl-3-(3-pyridyl)-5-(4-chlorophenyl)isoxazolidine and at least one other fungicide; reduced application rate, broadened spectrum; synergistic against phytopathogens BASF AKTIENGESELLSCHAFT (DE) 2008-02-21 US disclosed
WO-2007010036-A2 FUNGICIDALLY ACTIVE AGENT BASF AKTIENGESELLSCHAFT (DE) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090042725-A1 Fungicidal Mixtures Based on 3,5-Disubstituted N-Biphenyl-Pyrazolcarboxamides CBR3, CBR1, STS UTS2R 1584/4885LMNA 3397/4885MAPK1 3928/4885
US-20080076747-A1 Fungicidal Mixtures ERG28, CYP51A1, CASP7 UTS2R 3352/4885LMNA 3150/4885MAPK1 4018/4885
US-20090131462-A1 Fungicidally Active Agent DPM1, PPM1D, HPD UTS2R 4250/4885LMNA 4198/4885MAPK1 1105/4885
US-20080255107-A1 Fungicidal Mixtures Comprising N-[2-(Haloalk(Enyl)Oxy)Phenyl]Carboxamides CBR3, CBR1, NAT1 UTS2R 947/4885LMNA 2193/4885MAPK1 3525/4885
US-20090203523-A1 Fungicidal Mixtures Made From 1-Methylpyrazol-4-Ylcarboxanilides CTRL, CYP4X1, SNU13 UTS2R 2511/4885LMNA 2015/4885MAPK1 3759/4885
US-20080153701-A1 Fungicidal Mixtures STS, DDT, CYP4X1 UTS2R 1954/4885LMNA 2041/4885MAPK1 2434/4885
US-20080293798-A1 Fungicidal Mixtures Comprising Substituted 1-Methylpyrazol-4-Ylcarboxanilides CBR3, CBR1, CTRL UTS2R 2324/4885LMNA 1795/4885MAPK1 3240/4885
US-20100093738-A1 Fungicidal Compounds and Fungicidal Compositions CYP51A1, DPM1, ERG28 UTS2R 4848/4885LMNA 3210/4885MAPK1 2495/4885
US-20090042724-A1 Fungicidal mixtures based on 2,4-disubstituted n-biphenylpyrazolecarboxamides CBR3, CBR1, SNU13 UTS2R 1487/4885LMNA 3266/4885MAPK1 4229/4885
US-20080045414-A1 Of 2,3-dimethyl-3-(3-pyridyl)-5-(4-chlorophenyl)isoxazolidine and at least one other fungicide; reduced application rate, broadened spectrum; synergistic against phytopathogens DDT, CYP4X1, STS UTS2R 2493/4885LMNA 3033/4885MAPK1 3767/4885
US-20090239748-A1 Fungicidal Mixtures Based on 2,5-Disubstituted N-Biphenylpyrazolcarboxamides CBR3, CBR1, SNU13 UTS2R 1455/4885LMNA 3235/4885MAPK1 4038/4885
US-20090233795-A1 Fungicidal Mixtres Based On 3-Monosubstituted N-Bipenyl-Pyrazolecarboxamides CBR3, CBR1, CYCS UTS2R 1120/4885LMNA 3135/4885MAPK1 3748/4885
US-20090123561-A1 Fungicide mixtures based on 1-methyl-pyrazol-4-ylcarboxanilides CBR3, CBR1, CTRL UTS2R 2434/4885LMNA 2118/4885MAPK1 2973/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.