Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10995350 | 0.86 | ALDH1A1 (0.40) | AKR1C3HTTALDH1A1KMT2ALMNA | |
| SCHEMBL10994188 | 0.85 | KMT2A (0.38) | PPARDPPARAHTTALDH1A1KMT2A | |
| SCHEMBL10995319 | 0.85 | HTT (0.40) | HTTKMT2ALMNAHPGDMAPK1 | |
| SCHEMBL10996461 | 0.85 | LTA4H (0.40) | HTTALDH1A1KMT2ALMNAHPGD | |
| SCHEMBL10928513 | 0.71 | HPGD (0.46) | HTTALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL10926174 | 0.69 | LMNA (0.44) | HTTALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL10924941 | 0.68 | LMNA (0.53) | HTTALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL9818100 | 0.68 | AKR1C3 (0.75) | AKR1C3AKR1C2ALDH1A1KMT2AMAPT | |
| SCHEMBL317875 | 0.68 | AKR1C3 (0.75) | AKR1C3AKR1C2ALDH1A1KMT2AMAPT | |
| SCHEMBL22367457 | 0.67 | RIPK1 (0.36) | AKR1C3AKR1C2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4562186-A | HYPOTENSIVE, ANALGESICS, AND ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | claimed |
| US-4562186-A | HYPOTENSIVE, ANALGESICS, AND ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |