Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11358610 | 0.84 | CYP2C9 (0.50) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10992759 | 0.83 | ALDH1A1 (0.43) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10992991 | 0.77 | GAA (0.40) | CYP2C9CYP2C19CYP1A2CYP3A4SLC6A3 | |
| SCHEMBL5048646 | 0.77 | PPARG (0.35) | CYP2C9CYP1A2HSD17B10ALDH1A1TSHR | |
| SCHEMBL5047440 | 0.77 | L3MBTL1 (0.44) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10997357 | 0.74 | CYP3A4 (0.42) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11000515 | 0.73 | EPHX1 (0.50) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6983641 | 0.72 | MEN1 (0.46) | CYP1A2ALDH1A1SMN1; SMN2MEN1MAPT | |
| SCHEMBL10953879 | 0.72 | EPHX1 (0.49) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10989594 | 0.72 | CYP2C9 (0.48) | CYP2C9CYP2C19CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4535084-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4246263-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1981-01-20 | — | — | US | disclosed |