Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992481 | 0.93 | HTT (0.52) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| SCHEMBL10967698 | 0.87 | ALDH1A1 (0.49) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| SCHEMBL9539522 | 0.83 | NPSR1 (0.50) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| SCHEMBL10966368 | 0.81 | LMNA (0.50) | ALDH1A1NPSR1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL23063513 | 0.77 | ALDH1A1 (0.53) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| SCHEMBL10992447 | 0.72 | LMNA (0.51) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| SCHEMBL29092453 | 0.72 | HIF1A (0.49) | ALDH1A1NPSR1SMN1; SMN2HPGDMAPT | |
| SCHEMBL9539501 | 0.71 | NPSR1 (0.48) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| SCHEMBL10987849 | 0.71 | HTT (0.50) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL8798382 | 0.70 | ALDH1A1 (0.54) | ALDH1A1HTTNPSR1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | claimed |
| US-4528298-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-09 | — | — | US | disclosed |
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| EP-0043788-A1 | Imidazole derivatives, process for their preparation and their pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | disclosed |