Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540607 | 0.85 | GALR3 (0.44) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL9540657 | 0.83 | NPSR1 (0.43) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL10987849 | 0.80 | HTT (0.50) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL9539522 | 0.78 | NPSR1 (0.50) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL9539516 | 0.76 | SOAT1 (0.41) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL9526288 | 0.71 | F11 (0.36) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL10997238 | 0.71 | ALDH1A1 (0.52) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL10992447 | 0.70 | LMNA (0.51) | NPSR1KMT2AMEN1CYP3A4CYP2D6 | |
| SCHEMBL10970187 | 0.69 | KDM4E (0.48) | NPSR1CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL10992481 | 0.68 | HTT (0.52) | NPSR1KMT2AMEN1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993001183-A1 | IMIDAZOLE DERIVATIVE AS ACAT INHIBITOR | RHONE-POULENC RORER LIMITED (GB) | 1993-01-21 | — | — | WO | disclosed |
| EP-0523941-A1 | Imidazoles as ACAT inhibitor | RHONE-POULENC RORER LIMITED (GB) | 1993-01-20 | — | — | EP | disclosed |