Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MGAM | O43451 | 2/20 | 0.45 |
| ▸ | SI | P14410 | 2/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PDE6D | O43924 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798390 | 0.90 | ALDH1A1 (0.54) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL17956061 | 0.78 | NPC1 (0.52) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL9980465 | 0.77 | KDM4E (0.47) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL28096950 | 0.76 | PPARG (0.51) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL17955964 | 0.75 | NPC1 (0.48) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL2105872 | 0.75 | NPC1 (0.46) | ALDH1A1HTTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL17955991 | 0.75 | DRD2 (0.46) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL17955921 | 0.74 | MAOB (0.45) | ALDH1A1HTTSMN1; SMN2MAPTKDM4E | |
| SCHEMBL27975918 | 0.74 | TP53 (0.52) | ALDH1A1HTTHPGDSMN1; SMN2MAPT | |
| SCHEMBL27975917 | 0.74 | TP53 (0.52) | ALDH1A1HTTHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700826-A | SENSITIZATION OF CANCER CELLS TO DRUG | ONTOGEN CORPORATION (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0812829-A1 | Substituted imidazoles as modulators of multi-drug resistance | ONTOGEN CORPORATION (US) | 1997-12-17 | — | — | EP | disclosed |