SCHEMBL10998624

SCHEMBL10998624

C=CCc1ncc(N)c(O)n1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.35
DHFR P00374 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10998773 0.80
SCHEMBL10998778 0.80
SCHEMBL1397434 0.76 KDM4E (0.33) IMPDH2
SCHEMBL1397344 0.75 IMPDH2 (0.31) IMPDH2
SCHEMBL10998377 0.75 DHFR (0.33) DHFR
SCHEMBL11306419 0.72 DHFR (0.42) IMPDH2DHFR
SCHEMBL10714315 0.71 DHFR (0.39) DHFR
SCHEMBL8994063 0.71 XDH (0.34) IMPDH2
SCHEMBL458710 0.71 IMPDH2 (0.33) IMPDH2
SCHEMBL10996107 0.71 IMPDH2 (0.30) IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE31926-E Penicillins and salts thereof BOEHRINGER INGELHEIM GMBH (DE) 1985-06-25 US disclosed
US-4241056-A ANTIBIOTICS BOEHRINGER INGELHEIM GMBH (DE) 1980-12-23 US disclosed
EP-0003814-A2 Penicillins, their salts, process for their preparation and pharmaceutical compositions containing them Dr. Karl Thomae GmbH (DE) 1979-09-05 EP disclosed