Sugi Predict

Sugi Predict / Compounds / SCHEMBL109995

SCHEMBL109995

SCHEMBL109995

COc1ccc(-c2ccc(Nc3ccc(C(=O)N4CCN(C(=O)OC(C)(C)C)CC4)cc3)c(C#N)c2)cc1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 3/20 0.48
▸ CFTR P13569 2/20 0.48
▸ GALR2 O43603 1/20 0.46
▸ GALR1 P47211 1/20 0.46
▸ JAK2 O60674 2/20 0.45
▸ ABL1 P00519 3/20 0.42
▸ RIN1 Q13671 1/20 0.42
▸ HDAC4 P56524 1/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ CCNT1 O60563 1/20 0.41
▸ CCNA2 P20248 1/20 0.41
▸ CDK2 P24941 1/20 0.41
▸ CDK9 P50750 1/20 0.41
▸ CCNA1 P78396 1/20 0.41
▸ EPHX2 P34913 1/20 0.40
▸ PDE5A O76074 1/20 0.40
▸ DYRK2 Q92630 1/20 0.40
▸ ALK Q9UM73 1/20 0.39
▸ BCR P11274 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL144185 0.89 JAK2 (0.44) JAK2ABL1BCR
SCHEMBL13284482 0.87 CFTR (0.49) CFTRGALR2GALR1JAK2ABL1
SCHEMBL110337 0.81 KMT2A (0.47) GPR119CFTRJAK2ABL1RIN1
SCHEMBL110107 0.80 LMNA (0.50) JAK2
SCHEMBL149035 0.75 TYK2 (0.53) JAK2EPHX2
SCHEMBL109973 0.75 SRC (0.46) CFTRJAK2MEN1KMT2A
SCHEMBL110138 0.74 ABL1 (0.50) JAK2ABL1MEN1KMT2ABCR
SCHEMBL27005506 0.73 GPR119 (0.48) GPR119CFTR
SCHEMBL27005510 0.72 GPR119 (0.46) GPR119CFTRGALR2GALR1
SCHEMBL8252454 0.70 KMT2A (0.72) GPR119ABL1RIN1HDAC4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
EP-2370407-B1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-06-18 — — EP disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
EP-2370407-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2011-10-05 — — EP disclosed
WO-2010080474-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-07-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS JAK2, JAK1, JAK3 GPR119 855/4885CFTR 1681/4885GALR2 2205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.