Sugi Predict

Sugi Predict / Compounds / SCHEMBL110138

SCHEMBL110138

SCHEMBL110138

COc1cccc(-c2ccc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)c(C#N)c2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 6/20 0.50
▸ BCR P11274 6/20 0.50
▸ GAA P10253 1/20 0.50
▸ GHSR Q92847 1/20 0.49
▸ KDM4E B2RXH2 1/20 0.46
▸ MEN1 O00255 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ LMNA P02545 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ RECQL P46063 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ PIK3CD O00329 1/20 0.46
▸ PIK3CA P42336 1/20 0.46
▸ PIK3CB P42338 1/20 0.46
▸ PIK3CG P48736 1/20 0.46
▸ KCNH2 Q12809 1/20 0.46
▸ FGFR4 P22455 1/20 0.46
▸ JAK2 O60674 2/20 0.46
▸ BTK Q06187 1/20 0.46
▸ JAK1 P23458 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13284620 0.86 GAA (0.52) ABL1BCRGAAGHSRKDM4E
SCHEMBL109973 0.84 SRC (0.46) MEN1ALDH1A1MAPTKMT2AJAK2
SCHEMBL110327 0.79 POLB (0.52) MEN1LMNAKMT2APOLBMAPKAPK2
SCHEMBL144185 0.77 JAK2 (0.44) ABL1BCRMAPTJAK2TYK2
SCHEMBL110029 0.76 TP53 (0.54) GAAMEN1ALDH1A1KMT2APOLB
SCHEMBL110034 0.74 LRRK2 (0.53) GAAKDM4EMEN1ALDH1A1LMNA
SCHEMBL5465369 0.74 VCP (0.64) ABL1BCRGAAGHSRALDH1A1
SCHEMBL109995 0.74 GPR119 (0.48) ABL1BCRMEN1KMT2AJAK2
SCHEMBL13504020 0.73 ALDH1A1 (0.74) ABL1BCRGAAMEN1ALDH1A1
SCHEMBL142118 0.73 TTK (0.51) GAAALDH1A1MAPTPIK3CDJAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
US-8815840-B2 Carbazole and carboline kinase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2014-08-26 — — US disclosed
EP-2370407-B1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-06-18 — — EP disclosed
EP-2370407-B1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-06-18 — — EP disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2012-03-08 — — US disclosed
EP-2370407-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2011-10-05 — — EP disclosed
WO-2010080474-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2010-07-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120058988-A1 CARBAZOLE AND CARBOLINE KINASE INHIBITORS JAK2, JAK1, JAK3 ABL1 4/4885BCR 536/4885GAA 1883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.