Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 8/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641316 | 0.87 | OAT (0.37) | SRD5A2SRD5A1TSHRFFAR3GABRP | |
| SCHEMBL28201395 | 0.84 | — | — | |
| SCHEMBL10940131 | 0.78 | — | — | |
| SCHEMBL24731262 | 0.73 | GABRP (0.33) | SRD5A2SRD5A1TSHRGABRPGABRD | |
| SCHEMBL11372909 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL27325175 | 0.71 | OAT (0.35) | SRD5A2SRD5A1FFAR3OAT | |
| SCHEMBL6862905 | 0.70 | TSHR (0.39) | SRD5A2SRD5A1TSHRFFAR3GABRP | |
| SCHEMBL442745 | 0.70 | ALDH1A1 (0.33) | — | |
| SCHEMBL2410833 | 0.68 | SRD5A2 (0.33) | SRD5A2SRD5A1TSHRFFAR3GABRP | |
| SCHEMBL27647018 | 0.68 | ALDH1A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4496743-A | 1-[(Acylthiocycloalkyl)carbonyl]-L-proline derivatives | GRUPPO LEPETIT S.P.A. (IT) | 1985-01-29 | — | — | US | disclosed |
| US-4385062-A | 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents | GRUPPO LEPETIT S.P.A. (IT) | 1983-05-24 | — | — | US | disclosed |