Sugi Predict

Sugi Predict / Compounds / SCHEMBL1100748

SCHEMBL1100748

SCHEMBL1100748

Nc1c(F)cc(Br)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 5/20 0.48
▸ CA2 P00918 5/20 0.48
▸ CA9 Q16790 5/20 0.48
▸ ALDH1A1 P00352 3/20 0.40
▸ CYP3A4 P08684 1/20 0.40
▸ NMT1 P30419 1/20 0.35
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC6 Q9UBN7 1/20 0.33
▸ KDM1A O60341 4/20 0.32
▸ KDM1B Q8NB78 3/20 0.32
▸ DGAT1 O75907 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ CA12 O43570 1/20 0.32
▸ CA3 P07451 1/20 0.32
▸ CA4 P22748 1/20 0.32
▸ CA6 P23280 1/20 0.32
▸ CA5A P35218 1/20 0.32
▸ CA7 P43166 1/20 0.32
▸ CA13 Q8N1Q1 1/20 0.32
▸ CA14 Q9ULX7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1004957 0.82 CYP3A4 (0.58) CA1CA2CA9ALDH1A1CYP3A4
SCHEMBL58096 0.82 HDAC1 (0.44) CA1CA2CA9ALDH1A1CYP3A4
Succinchlorimide SCHEMBL1101781 0.81 CA1 (0.39) CA1CA2CA9ALDH1A1DGAT1
Hydrochloric Acid SCHEMBL8367686 0.79 CYP3A4 (0.55) CA1CA2CA9ALDH1A1CYP3A4
SCHEMBL17200660 0.76 CA1 (0.48) CA1CA2CA9ALDH1A1CYP3A4
SCHEMBL231997 0.75 CA1 (0.39) CA1CA2CA9ALDH1A1HDAC1
SCHEMBL6217810 0.75 CA1 (0.54) CA1CA2CA9ALDH1A1CYP3A4
SCHEMBL899027 0.75 CA1 (0.52) CA1CA2CA9ALDH1A1CYP3A4
SCHEMBL14956328 0.75 NMT1 (0.38) ALDH1A1NMT1KDM1AKDM1BDGAT1
SCHEMBL1639935 0.75 CA1 (0.54) CA1CA2CA9CYP3A4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 160 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117658763-A Preparation method of 5-bromo-1, 2-dichloro-3-fluorobenzene 棓诺(苏州)新材料有限公司 2024-03-08 — — CN claimed
US-12552772-B2 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD SPRINGWORKS THERAPEUTICS, INC. (US) 2026-02-17 — — US disclosed
US-20250179059-A1 ANTICANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2025-06-05 — — US disclosed
CN-119912402-A FTO inhibitor and preparation method and application thereof 中国科学院上海药物研究所 2025-05-02 — — CN disclosed
US-20250115574-A1 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD VIB VZW (BE) 2025-04-10 — — US disclosed
US-12162870-B2 Anticancer compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-12-10 — — US disclosed
EP-4452253-A2 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD The Katholieke Universiteit Leuven (BE) 2024-10-30 — — EP disclosed
CN-114829543-B Aromatic isothiocyanates 默克专利股份有限公司 2024-09-10 — — CN disclosed
WO-2024152993-A1 FUSED RING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE 上海泽德曼医药科技有限公司 2024-07-25 — — WO disclosed
US-12030866-B2 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD SPRINGWORKS THERAPEUTICS, INC. (US) 2024-07-09 — — US disclosed
WO-2011138665-A1 NOVEL IMMUNOMODULATOR AND ANTI INFLAMMATORY COMPOUNDS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2011-11-10 — — WO disclosed
US-20110275603-A1 NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS RHIZEN PHARMACEUTICALS SA (FR) 2011-11-10 — — US disclosed
WO-2011103546-A1 TRIAZOLONES AS FATTY ACID SYNTHASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2011-08-25 — — WO disclosed
CN-101048410-B HIV inhibiting bicyclic pyrimidine derivatives TIBOTEC PHARM LTD 2010-06-23 — — CN disclosed
US-20080085907-A1 Hiv Inhibiting Bicyclic Pyrimdine Derivatives JANSSEN-CILAG (FR) 2008-04-10 — — US disclosed
US-20080085907-A1 Hiv Inhibiting Bicyclic Pyrimdine Derivatives JANSSEN-CILAG (FR) 2008-04-10 — — US disclosed
US-20080085907-A1 Hiv Inhibiting Bicyclic Pyrimdine Derivatives JANSSEN-CILAG (FR) 2008-04-10 — — US disclosed
CN-101048410-A HIV inhibiting bicyclic pyrimidine derivatives TIBOTEC PHARM LTD (IE) 2007-10-03 — — CN disclosed
EP-1807430-A1 HIV INHIBITING BICYCLIC PYRIMIDINE DERIVATIVES Tibotec Pharmaceuticals Ltd. (IE) 2007-07-18 — — EP disclosed
WO-2006045828-A1 HIV INHIBITING BICYCLIC PYRIMIDINE DERIVATIVES TIBOTEC PHARMACEUTICALS LTD. (IE) 2006-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179059-A1 ANTICANCER COMPOUNDS BET1, BRD4, BICRA CA1 4280/4885CA2 2972/4885CA9 2358/4885
US-12552772-B2 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD YAP1, TEAD3, TEAD2 CA1 4878/4885CA2 3687/4885CA9 3479/4885
US-20080085907-A1 Hiv Inhibiting Bicyclic Pyrimdine Derivatives CCR6, CD4, CCNT1 CA1 4620/4885CA2 4321/4885CA9 4331/4885
US-20110275603-A1 NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS DHODH, DLD, DHFR CA1 2391/4885CA2 1430/4885CA9 2095/4885
US-12030866-B2 2-pyrazole anilines and related analogs for inhibiting YAP/TAZ-TEAD YAP1, TEAD3, TEAD2 CA1 4878/4885CA2 4583/4885CA9 4753/4885
US-20250115574-A1 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD YAP1, TEAD3, TEAD2 CA1 4878/4885CA2 4583/4885CA9 4753/4885
US-12162870-B2 Anticancer compounds BET1, BRD4, BICRA CA1 4280/4885CA2 2972/4885CA9 2358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.