Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007258 | 0.83 | NAAA (0.48) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL11002451 | 0.80 | KMT2A (0.40) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL11005524 | 0.80 | KMT2A (0.43) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL11167676 | 0.75 | AGXT (0.55) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL11005214 | 0.74 | IDO1 (0.46) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL11010407 | 0.74 | SIGMAR1 (0.44) | DPP4DPP8NAAASIGMAR1 | |
| SCHEMBL11167252 | 0.74 | KMT2A (0.39) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL11004925 | 0.72 | IDO1 (0.49) | DPP4DPP8DPP9DPP7NAAA | |
| SCHEMBL11160529 | 0.70 | DPP4 (0.41) | DPP4DPP8NAAASIGMAR1 | |
| SCHEMBL11003582 | 0.70 | IDO1 (0.45) | DPP4FAPDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4517183-A | COMBATING DISEASES WITH WEAKNESS OF IMMUNE SYSTEMS | BOEHRINGER MANNHEIM GMBH (DE) | 1985-05-14 | — | — | US | disclosed |
| US-4397848-A | ANTITUMOR ACTIVITY | BOEHRINGER MANNHEIM GMBH (DE) | 1983-08-09 | — | — | US | disclosed |
| EP-0014976-B1 | N-SUBSTITUTED 2-CYANAZIRIDINES, METHODS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM, CORRESPONDINGLY SUBSTITUTED AZIRIDINE-2-CARBONAMIDES AND THEIR PREPARATION | Roche Diagnostics GmbH (DE) | 1982-04-07 | — | — | EP | disclosed |
| EP-0014976-A1 | N-substituted 2-cyanaziridines, methods for their preparation and medicaments containing them, correspondingly substituted aziridine-2-carbonamides and their preparation | Roche Diagnostics GmbH (DE) | 1980-09-03 | — | — | EP | disclosed |