Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11006118 | 0.89 | MAPT (0.56) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL11010621 | 0.87 | TP53 (0.56) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL24105991 | 0.87 | TP53 (0.67) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL11012504 | 0.85 | MAPT (0.51) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL24106012 | 0.83 | THRB (0.70) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL11015064 | 0.81 | TP53 (0.73) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL11005976 | 0.80 | TP53 (0.55) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL11007567 | 0.80 | ADORA2A (0.61) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL9837374 | 0.80 | RAB9A (0.53) | TP53MAPTSMN1; SMN2TSHRLMNA | |
| SCHEMBL9569354 | 0.80 | MAPT (0.56) | TP53MAPTSMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4497817-A | ANTIALLERGENS-IMMUNOSUPPRESSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1985-02-05 | — | — | US | claimed |
| EP-0144341-A4 | NOVEL 4,5-g(a)EPOXYMORPHINAN-6-SPIRO-2'-(4'-CARBOXY,1',3'-THIAZOLIDINE) DERIVATIVES. | KEY PHARMA (US) | 1985-07-30 | — | — | EP | disclosed |
| EP-0144341-A1 | NOVEL 4,5-g(a)EPOXYMORPHINAN-6-SPIRO-2'-(4'-CARBOXY,1',3'-THIAZOLIDINE) DERIVATIVES. | KEY PHARMA (US) | 1985-06-19 | — | — | EP | disclosed |
| US-4497817-A | ANTIALLERGENS-IMMUNOSUPPRESSIVE AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1985-02-05 | — | — | US | disclosed |
| WO-1984003627-A1 | NOVEL 4,5alphaEPOXYMORPHINAN-6-SPIRO-2'-(4'-CARBOXY,1',3'-THIAZOLIDINE) DERIVATIVES | KEY PHARMA (US) | 1984-09-27 | — | — | WO | disclosed |