⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620009 | 0.72 | — | — | |
| SCHEMBL151371 | 0.68 | — | — | |
| SCHEMBL617149 | 0.67 | — | — | |
| SCHEMBL618855 | 0.66 | — | — | |
| SCHEMBL299619 | 0.66 | — | — | |
| SCHEMBL2394043 | 0.65 | — | — | |
| SCHEMBL6508630 | 0.65 | ALDH1A1 (0.38) | — | |
| SCHEMBL486493 | 0.65 | — | — | |
| SCHEMBL617265 | 0.64 | CYP3A4 (0.32) | — | |
| SCHEMBL1078460 | 0.64 | SIGMAR1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708541-B1 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis | ISIS PHARMACEUTICALS INC (US) | 2015-01-28 | — | — | EP | claimed |
| EP-2708541-A1 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis | Isis Pharmaceuticals, Inc. (US) | 2014-03-19 | — | — | EP | claimed |
| EP-2708541-B1 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis | ISIS PHARMACEUTICALS INC (US) | 2015-01-28 | — | — | EP | disclosed |
| EP-2708541-A1 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis | Isis Pharmaceuticals, Inc. (US) | 2014-03-19 | — | — | EP | disclosed |
| US-8541599-B2 | Supports for oligomer synthesis | ISIS PHARMACEUTICALS, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-20120165547-A1 | SUPPORTS FOR OLIGOMER SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8153725-B2 | Supports for oligomer synthesis | ISIS PHARMACEUTICALS, INC (US) | 2012-04-10 | — | — | US | disclosed |
| CN-102234359-A | Conjugated diene polymer, conjugated diene polymer composition, and method for producing conjugated diene polymer | SUMITOMO CHEMICAL CO | 2011-11-09 | — | — | CN | disclosed |
| US-20100234528-A1 | SUPPORTS FOR OLIGOMER SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7718810-B2 | Supports such as glass and styrene polymers functionalized with tricyclic hetercyclic anhydrides and imides, used in the preparation of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7576119-B2 | Supports for oligomer synthesis | ISIS PHARMACEUTICALS, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20090131682-A1 | SUPPORTS FOR OLIGOMER SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20080021224-A1 | SUPPORTS FOR OLIGOMER SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2008-01-24 | — | — | US | disclosed |
| US-7202264-B2 | Supports such as glass and styrene polymers functionalized with tricyclic hetercyclic anhydrides and imides, used in the preparation of oligonucleotides | ISIS PHARMACEUTICALS, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050208588-A1 | Supports for oligomer synthesis | ISIS PHARMACEUTICALS, INC. (US) | 2005-09-22 | — | — | US | disclosed |
| EP-1453815-A4 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| EP-1453815-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | Merck & Co., Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003048137-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |