Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL5066663 | 1.00 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| Potassium Ion SCHEMBL5066748 | 1.00 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| Potassium Ion SCHEMBL5066767 | 1.00 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| Lithium Ion SCHEMBL5069418 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| SCHEMBL5066670 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| SCHEMBL5063907 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| SCHEMBL5066665 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| Lithium Ion SCHEMBL5070207 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| Lithium Ion SCHEMBL5070255 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT | |
| SCHEMBL8391941 | 0.96 | TSHR (0.36) | TSHRKDM4ETDP1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE31907-E | VARIATION IN CONCENTRATION OF COMONOMER BETWEEN CORE AND SHELL | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| US-4036802-A | Tetrafluoroethylene copolymer fine powder resin | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-07-19 | — | — | US | disclosed |