Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 19/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11016885 | 0.92 | CHEK2 (0.53) | CHEK2MAPK1 | |
| SCHEMBL11016463 | 0.92 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11017897 | 0.91 | PDE4A (0.44) | CHEK2 | |
| SCHEMBL11019650 | 0.90 | CHEK2 (0.43) | CHEK2 | |
| SCHEMBL11022048 | 0.89 | CHEK2 (0.55) | CHEK2 | |
| SCHEMBL11016890 | 0.84 | CHEK2 (0.63) | CHEK2MAPK1 | |
| SCHEMBL11017902 | 0.82 | CHEK2 (0.53) | CHEK2 | |
| SCHEMBL11019652 | 0.82 | CHEK2 (0.52) | CHEK2 | |
| SCHEMBL11022051 | 0.80 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11020236 | 0.79 | CHEK2 (0.48) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |