Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 19/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11016885 | 0.92 | CHEK2 (0.53) | CHEK2MEN1LMNATP53CYP1A2 | |
| SCHEMBL11016463 | 0.92 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11022051 | 0.87 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL11016458 | 0.84 | CHEK2 (0.55) | CHEK2MAPK1 | |
| SCHEMBL11017902 | 0.83 | CHEK2 (0.53) | CHEK2TP53 | |
| SCHEMBL11020867 | 0.83 | TP53 (0.51) | CHEK2MEN1LMNATP53CYP1A2 | |
| SCHEMBL11019181 | 0.82 | TP53 (0.55) | CHEK2MEN1LMNATP53CYP1A2 | |
| SCHEMBL11019652 | 0.82 | CHEK2 (0.52) | CHEK2LMNA | |
| SCHEMBL11017363 | 0.80 | AR (0.50) | CHEK2MEN1LMNATP53CYP1A2 | |
| SCHEMBL11019275 | 0.80 | CHEK2 (0.48) | CHEK2MEN1LMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |