Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017088 | 0.93 | CHEK2 (0.47) | DHFRALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL11019173 | 0.81 | POLB (0.47) | LMNAHPGDCHEK2HPSEPOLB | |
| SCHEMBL11017897 | 0.79 | PDE4A (0.44) | CHEK2HPSEPOLBMAPTTDP1 | |
| SCHEMBL11020863 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1LMNAKDM4EHPGDCHEK2 | |
| SCHEMBL11016458 | 0.79 | CHEK2 (0.55) | CHEK2 | |
| SCHEMBL11019650 | 0.79 | CHEK2 (0.43) | ALDH1A1LMNAKDM4EHPGDCHEK2 | |
| SCHEMBL11019019 | 0.77 | HPSE (0.42) | ALDH1A1HPGDCHEK2HPSEPOLB | |
| SCHEMBL11017084 | 0.76 | ALDH1A1 (0.41) | DHFRALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL7272133 | 0.76 | PDE5A (0.42) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL11019181 | 0.73 | TP53 (0.55) | LMNAHPGDCHEK2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |