Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | CFB | P00751 | 4/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11017158 | 0.91 | PKN1 (0.46) | AMY1APKN1PKN2CFBCHEK2 | |
| SCHEMBL10764183 | 0.91 | MAPK10 (0.41) | MAPK10AMY1APDE5APKN1PKN2 | |
| SCHEMBL10767330 | 0.89 | MAPK10 (0.39) | MAPK10AMY1APDE5APDE3BPDE3A | |
| SCHEMBL11018065 | 0.89 | PDE5A (0.37) | MAPK10PDE5APKN1PKN2RHEB | |
| SCHEMBL11021159 | 0.87 | MAPK10 (0.38) | MAPK10AMY1APDE5APDE3BPDE3A | |
| SCHEMBL10578096 | 0.84 | AMY1A (0.37) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL10748660 | 0.82 | CDK4 (0.46) | MAPK10AMY1APDE5APDE3BPDE3A | |
| SCHEMBL10765920 | 0.80 | AMY1A (0.39) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL11021893 | 0.80 | ATR (0.44) | MAPK10AMY1APDE5APDE3BPDE3A | |
| SCHEMBL10759909 | 0.80 | RHEB (0.53) | PKN1PKN2RHEBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |