Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | CFB | P00751 | 5/20 | 0.33 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021164 | 0.92 | PKN1 (0.42) | AMY1AF7CFBPKN1PKN2 | |
| SCHEMBL10767330 | 0.92 | MAPK10 (0.39) | MAPK10AMY1APDE5APDE3BPDE3A | |
| SCHEMBL11017149 | 0.87 | MAPK10 (0.41) | MAPK10AMY1APDE5APDE3BPDE3A | |
| SCHEMBL11018557 | 0.84 | PKN1 (0.44) | AMY1AF7CFBPKN1PKN2 | |
| SCHEMBL7272018 | 0.81 | PDE5A (0.47) | AMY1APDE5APDE3BPDE3APDE2A | |
| SCHEMBL11018065 | 0.80 | PDE5A (0.37) | MAPK10PDE5APKN1PKN2RHEB | |
| SCHEMBL10763275 | 0.79 | MAPK10 (0.42) | MAPK10PDE5APDE3BPDE3A | |
| SCHEMBL11061395 | 0.79 | PDE5A (0.39) | PDE5A | |
| SCHEMBL11017158 | 0.79 | PKN1 (0.46) | AMY1ACFBPKN1PKN2 | |
| SCHEMBL10764183 | 0.79 | MAPK10 (0.41) | MAPK10AMY1APDE5AF7CFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |