Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020863 | 0.93 | SMN1; SMN2 (0.44) | TP53LMNAMEN1CYP1A2HPGD | |
| SCHEMBL11019181 | 0.90 | TP53 (0.55) | TP53LMNAMEN1CYP1A2HPGD | |
| SCHEMBL11019652 | 0.84 | CHEK2 (0.52) | LMNAL3MBTL1MAPTCHEK2F2 | |
| SCHEMBL11016890 | 0.83 | CHEK2 (0.63) | TP53LMNAMEN1CYP1A2HPGD | |
| SCHEMBL11019173 | 0.83 | POLB (0.47) | TP53LMNAMEN1CYP1A2HPGD | |
| SCHEMBL11017088 | 0.79 | CHEK2 (0.47) | TP53LMNAHPGDL3MBTL1NPC1 | |
| SCHEMBL11019907 | 0.79 | CHEK2 (0.53) | LMNAHPGDSMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL11019023 | 0.79 | CHEK2 (0.48) | TP53MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL11018042 | 0.79 | CHEK2 (0.48) | TP53LMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL11019646 | 0.78 | MAPT (0.47) | TP53LMNAL3MBTL1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |