Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018835 | 0.92 | MEN1 (0.47) | PDE2AMAOBMEN1NPC1TP53 | |
| SCHEMBL11017854 | 0.91 | MAOB (0.43) | MAOBMEN1NPC1TP53PKM | |
| SCHEMBL11018202 | 0.85 | PDE2A (0.43) | PDE2AMAOBAMY1ATOP1TOP2A | |
| SCHEMBL11020236 | 0.85 | CHEK2 (0.48) | PDE2A | |
| SCHEMBL11019245 | 0.84 | CHEK2 (0.44) | PDE2ANPC1TP53POLBHPGD | |
| SCHEMBL9634540 | 0.83 | PDE5A (0.47) | PDE2AMAOBMEN1HPGDKMT2A | |
| SCHEMBL11036642 | 0.83 | PDE2A (0.41) | PDE2AAMY1ATOP1TOP2APDE5A | |
| SCHEMBL11018765 | 0.83 | SCD (0.41) | PDE2AMAOBNPC1PKMHPGD | |
| SCHEMBL11020385 | 0.83 | AMY1A (0.50) | PDE2AMEN1NPC1KMT2AALDH1A1 | |
| SCHEMBL10733841 | 0.83 | PDE2A (0.46) | PDE2AMAOBMEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |