Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 13/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018071 | 0.93 | CYP2C9 (0.47) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11018186 | 0.92 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL11021893 | 0.89 | ATR (0.44) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11020313 | 0.88 | CA2 (0.54) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11016112 | 0.87 | SCN9A (0.42) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11018857 | 0.87 | MAPT (0.44) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11017633 | 0.86 | ALDH1A1 (0.44) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11021552 | 0.86 | L3MBTL1 (0.47) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11018077 | 0.85 | CYP2C9 (0.54) | CYP3A4CYP2C9CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL11022213 | 0.82 | ATR (0.44) | SCDPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209707-A2 | 2-Aryl imidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-01-28 | — | — | EP | disclosed |
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |