Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11016192 | 0.82 | HRH4 (0.53) | CA1CA2 | |
| Hydrochloric Acid SCHEMBL11023242 | 0.81 | HRH4 (0.52) | CA1CA2 | |
| SCHEMBL11038105 | 0.80 | SCN9A (0.46) | MEN1KMT2AKDM4EPLAUKDM5A | |
| SCHEMBL28991763 | 0.78 | L3MBTL1 (0.47) | MAPTNPC1RAB9AMEN1LMNA | |
| SCHEMBL10966483 | 0.78 | DYRK1A (0.36) | PDPK1CA1CA2MEN1KMT2A | |
| SCHEMBL2780925 | 0.76 | LMNA (0.42) | MAPTLMNAKDM4EALDH1A1GAA | |
| SCHEMBL10399713 | 0.76 | NR3C2 (0.45) | AURKAMAPTCA1CA2MAPK8 | |
| SCHEMBL10310327 | 0.74 | TAS2R14 (0.47) | SYKGAA | |
| SCHEMBL11023223 | 0.73 | CYP2D6 (0.34) | KMT2A | |
| SCHEMBL29091384 | 0.73 | MAPK8 (0.56) | AURKAMAPTNPC1RAB9AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062439-B1 | GUANIDINOPYRIMIDINES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-03-20 | — | — | EP | disclosed |
| EP-0062439-A1 | Guanidinopyrimidines | SMITHKLINE BECKMAN CORPORATION (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4336254-A | Guanidinopyrimidine compounds, compositions and method of using as a diuretic | SMITHKLINE CORPORATION (US) | 1982-06-22 | — | — | US | disclosed |