Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LARS1 | Q9P2J5 | 5/20 | 0.60 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.48 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.47 |
| ▸ | CASR | P41180 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | KYNU | Q16719 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL11803673 | 1.00 | LARS1 (0.60) | LARS1SLC7A5TSHRSMN1; SMN2ANPEP | |
| Leucine SCHEMBL21352573 | 0.89 | LARS1 (0.49) | LARS1SLC7A5ANPEPRNPEPDNPEP | |
| Leucine SCHEMBL16464665 | 0.88 | SLC7A5 (0.55) | LARS1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Leucine SCHEMBL9592701 | 0.88 | SLC7A5 (0.55) | LARS1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Leucine SCHEMBL29575582 | 0.88 | SLC7A5 (0.55) | LARS1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Leucine SCHEMBL30462445 | 0.88 | SLC7A5 (0.55) | LARS1SLC7A5SLC1A3SLC1A2SLC1A1 | |
| Leucine SCHEMBL8045916 | 0.85 | SLC7A5 (0.51) | LARS1SLC7A5ANPEPRNPEPDNPEP | |
| Leucine SCHEMBL8047098 | 0.85 | SLC7A5 (0.51) | LARS1SLC7A5ANPEPRNPEPDNPEP | |
| D-Leucine SCHEMBL8053196 | 0.85 | SLC7A5 (0.51) | LARS1SLC7A5ANPEPRNPEPDNPEP | |
| SCHEMBL4660559 | 0.84 | TSHR (0.52) | LARS1SLC7A5TSHRSMN1; SMN2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-51149222-A | — | — | None | — | — | JP | disclosed |
| EP-0057092-B1 | PROCESS FOR RACEMIZING AN OPTICALLY ACTIVE ALPHA-AMINO ACID OR A SALT THEREOF | Tanabe Seiyaku Co., Ltd. (JP) | 1985-05-02 | — | — | EP | disclosed |
| US-4427680-A | ANTHISTAMINES | BOEHRINGER MANNHEIM GMBH (DE) | 1984-01-24 | — | — | US | disclosed |
| US-4401820-A | IN THE PRESENCE OF AN ACYCLIC ACID AND AN ALDEHYDE; STABILITY | TANABE SEIYAKU CO., LTD. (JP) | 1983-08-30 | — | — | US | disclosed |
| EP-0057092-A1 | Process for racemizing an optically active alpha-amino acid or a salt thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1982-08-04 | — | — | EP | disclosed |
| JP-S51149222-A | PREPARATION OF HIGHLY PURIFIED LEUCINE | TANABE SEIYAKU CO LTD | 1976-12-22 | — | — | JP | disclosed |