Known targets — ChEMBL curated mechanism
BTKCACNA1CCACNA1DCACNA1FCACNA1SCACNA2D1CACNA2D2DRD2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQHRH1HTR2AP2RY12
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 4/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.42 |
| ▸ | KYNU | Q16719 | 2/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL538085 | 0.87 | TSHR (0.55) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Aspartic Acid SCHEMBL538084 | 0.87 | TSHR (0.55) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Leucine SCHEMBL11803673 | 0.84 | LARS1 (0.60) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Leucine SCHEMBL11024352 | 0.84 | LARS1 (0.60) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Dl-Phenylalanine SCHEMBL25434213 | 0.82 | SLC7A5 (0.73) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Phenylalanine SCHEMBL25434211 | 0.82 | SLC7A5 (0.73) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Aspartic Acid SCHEMBL28088617 | 0.80 | TSHR (0.47) | TSHRSMN1; SMN2ALPIPKMPTGS1 | |
| Alanine SCHEMBL10627958 | 0.79 | TSHR (0.64) | TSHRSMN1; SMN2CASRLARS1SLC1A3 | |
| Alanine SCHEMBL10626231 | 0.79 | TSHR (0.64) | TSHRSMN1; SMN2CASRLARS1SLC1A3 | |
| Aspartic Acid SCHEMBL9386444 | 0.78 | TSHR (0.44) | TSHRSMN1; SMN2ALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007711-A1 | 5-AMINOLEVULINIC ACID SALTS AND THEIR USE | Bar Ilan University (IL) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007107998-A1 | 5-AMINOLEVULINIC ACID SALTS AND THEIR USE | BAR ILAN UNIVERSITY (IL) | 2007-09-27 | — | — | WO | disclosed |