Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HTR1B | P28222 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022872 | 0.91 | KDM4E (0.52) | KDM4EHTR1BHRH1HTR7ALDH1A1 | |
| SCHEMBL11021248 | 0.90 | KDM4E (0.53) | KDM4EHTR1BHRH1HTR7ALDH1A1 | |
| SCHEMBL12603012 | 0.85 | HRH1 (0.60) | KDM4EHTR1BHRH1 | |
| SCHEMBL11018477 | 0.84 | L3MBTL1 (0.47) | KDM4E | |
| SCHEMBL11020827 | 0.83 | L3MBTL1 (0.46) | KDM4EHTR1BSMN1; SMN2 | |
| SCHEMBL11019492 | 0.82 | HTR7 (0.56) | KDM4EHTR1BHRH1HTR7ALDH1A1 | |
| SCHEMBL11019533 | 0.81 | KDM4E (0.58) | KDM4EHTR1BHRH1HTR7ALDH1A1 | |
| SCHEMBL11018699 | 0.80 | ADRB2 (0.52) | KDM4EHTR1BALDH1A1ADRB2 | |
| SCHEMBL11022396 | 0.79 | HTR7 (0.61) | KDM4EHTR1BHRH1HTR7ALDH1A1 | |
| SCHEMBL11017224 | 0.78 | KDM4E (0.83) | KDM4EHTR1BHTR7ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157652-A1 | 2-, 3- And 4-biphenyloxyaminoalkanes and related compounds, their preparation and uses, and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1985-10-09 | — | — | EP | disclosed |