Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.51 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11023582 | 0.94 | OPRM1 (0.54) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11024037 | 0.91 | OPRM1 (0.58) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11027738 | 0.91 | HTR1A (0.60) | OPRM1DRD2HTR1AHTR2ACHRM1 | |
| SCHEMBL11024716 | 0.91 | CHRM1 (0.58) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11026251 | 0.90 | CHRM1 (0.51) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11022277 | 0.90 | CHRM1 (0.54) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11099809 | 0.90 | HTR1A (0.55) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11096050 | 0.89 | DRD2 (0.62) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11026375 | 0.89 | OPRM1 (0.55) | OPRM1DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL11023574 | 0.88 | CHRM1 (0.54) | OPRM1DRD2HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068261-B1 | N-OXACYCLYL-ALKYLPIPERIDINE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4470989-A | Neuroleptic n-oxacyclyl-alkylpiperidine derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-09-11 | — | — | US | disclosed |