Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028602 | 0.88 | MTNR1A (0.47) | PYGLMTNR1AMTNR1BCTRB1 | |
| SCHEMBL11089192 | 0.88 | MTNR1A (0.47) | PYGLMTNR1AMTNR1BCTRB1 | |
| SCHEMBL11026867 | 0.86 | MTNR1A (0.45) | PYGLMTNR1AMTNR1BCTRB1 | |
| SCHEMBL11030131 | 0.84 | MTNR1A (0.43) | POLBMTNR1AMTNR1BCTRB1 | |
| Hydrochloric Acid SCHEMBL11026585 | 0.82 | LTA4H (0.52) | PYGLATMLTA4HPOLBKLK5 | |
| SCHEMBL22886596 | 0.78 | LTA4H (0.52) | PYGLATMLTA4HPOLBKLK5 | |
| SCHEMBL19258128 | 0.78 | LTA4H (0.52) | PYGLATMLTA4HPOLBKLK5 | |
| SCHEMBL7418811 | 0.77 | TRPM8 (0.69) | PYGLATMLTA4HTRPM8CTRB1 | |
| SCHEMBL5652568 | 0.77 | TRPM8 (0.55) | PYGLATMLTA4HPOLBKLK5 | |
| SCHEMBL8163494 | 0.77 | TRPM8 (0.69) | PYGLATMLTA4HTRPM8CTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077274-B1 | 3-AMINO-2-HYDROXY-4-PHENYLBUTANOIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1985-08-28 | — | — | EP | claimed |
| EP-0077274-A1 | 3-Amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical composition containing the same | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1983-04-20 | — | — | EP | claimed |
| US-4474764-A | ANALGESICS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1984-10-02 | — | — | US | disclosed |