Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28419373 | 0.80 | GAA (0.46) | MEN1ALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL2944896 | 0.72 | RAB9A (0.42) | MEN1ALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL4264509 | 0.70 | HTT (0.38) | ALDH1A1KMT2A | |
| SCHEMBL9682894 | 0.69 | BCL6 (0.47) | GAAMAPTMAPK1RAB9A | |
| SCHEMBL11022700 | 0.68 | MAPT (0.33) | MAPT | |
| SCHEMBL31548018 | 0.68 | MAP3K5 (0.47) | — | |
| SCHEMBL497359 | 0.68 | MAP3K5 (0.47) | — | |
| SCHEMBL11038105 | 0.68 | SCN9A (0.46) | MEN1KMT2A | |
| SCHEMBL2780925 | 0.67 | LMNA (0.42) | ALDH1A1GAAMAPT | |
| SCHEMBL135748 | 0.67 | LMNA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0062439-B1 | GUANIDINOPYRIMIDINES | SMITHKLINE BECKMAN CORPORATION (US) | 1985-03-20 | — | — | EP | disclosed |
| EP-0062439-A1 | Guanidinopyrimidines | SMITHKLINE BECKMAN CORPORATION (US) | 1982-10-13 | — | — | EP | disclosed |
| US-4336254-A | Guanidinopyrimidine compounds, compositions and method of using as a diuretic | SMITHKLINE CORPORATION (US) | 1982-06-22 | — | — | US | disclosed |