Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.54 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024944 | 0.91 | DRD2 (0.52) | DRD2DRD3DRD4GRM2CCR5 | |
| SCHEMBL19697436 | 0.83 | DRD2 (0.51) | DRD2DRD3DRD4GRM2CCR5 | |
| SCHEMBL11027135 | 0.82 | SLC18A3 (0.69) | DRD2MEN1KMT2ASLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8660067 | 0.80 | SLC18A3 (0.67) | DRD2MEN1KMT2ASLC18A3SIGMAR1 | |
| SCHEMBL11021738 | 0.80 | DRD2 (0.75) | DRD2DRD3DRD4GRM2KCNH2 | |
| SCHEMBL10078845 | 0.80 | QDPR (0.53) | DRD2DRD3DRD4GRM2SLC6A4 | |
| SCHEMBL10265025 | 0.78 | DRD2 (0.47) | DRD2DRD3DRD4GRM2CCR5 | |
| SCHEMBL1067433 | 0.77 | SLC6A3 (0.53) | DRD2DRD3DRD4GRM2MEN1 | |
| SCHEMBL29940424 | 0.77 | SLC6A3 (0.53) | DRD2DRD3DRD4GRM2MEN1 | |
| Alcohol SCHEMBL10520510 | 0.77 | DRD2 (0.50) | DRD2DRD3DRD4GRM2SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |