Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11027883 | 0.91 | DRD2 (0.54) | DRD2DRD3DRD4GRM2SIGMAR1 | |
| SCHEMBL2554214 | 0.83 | SIGMAR1 (0.69) | DRD2SIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL11023284 | 0.81 | DRD2 (0.71) | DRD2DRD3DRD4SIGMAR1MEN1 | |
| Hydrochloric Acid SCHEMBL7255548 | 0.81 | SIGMAR1 (0.67) | DRD2SIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL7949583 | 0.79 | DRD2 (0.54) | DRD2DRD3DRD4KCNH2 | |
| SCHEMBL15748120 | 0.78 | DRD2 (0.57) | DRD2DRD3DRD4GRM2TSHR | |
| SCHEMBL10078845 | 0.78 | QDPR (0.53) | DRD2DRD3DRD4GRM2SLC6A2 | |
| SCHEMBL23739762 | 0.77 | HTR1A (0.46) | DRD2DRD3DRD4GRM2HRH3 | |
| SCHEMBL7963919 | 0.77 | HSD17B10 (0.53) | DRD2DRD3DRD4HRH3 | |
| SCHEMBL10265025 | 0.76 | DRD2 (0.47) | DRD2DRD3DRD4GRM2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040793-B1 | NOVEL QUINAZOLINE-DIONE COMPOUNDS, PROCESS FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | Ishikawa, Masayuki (JP) | 1985-08-28 | — | — | EP | disclosed |
| US-4405623-A | HYPOTENSIVE AGENTS, VASODILATORS | MASAYUKI ISHIKAWA (JP) | 1983-09-20 | — | — | US | disclosed |
| EP-0040793-A1 | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof | Ishikawa, Masayuki (JP) | 1981-12-02 | — | — | EP | disclosed |