Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 3/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9044564 | 0.71 | KCNH2 (0.38) | GNAI3GNAO1GNAI1MEN1KMT2A | |
| SCHEMBL90273 | 0.68 | GNAI3 (0.34) | GNAI3GNAO1GNAI1MEN1KMT2A | |
| SCHEMBL9905528 | 0.68 | GNAO1 (0.40) | GNAI3GNAO1GNAI1KCNH2 | |
| SCHEMBL27465544 | 0.67 | GNAI3 (0.37) | GNAI3GNAO1GNAI1MEN1KMT2A | |
| SCHEMBL27548581 | 0.67 | GNAI3 (0.37) | GNAI3GNAO1GNAI1MEN1KMT2A | |
| SCHEMBL7287866 | 0.64 | GNAO1 (0.34) | GNAI3GNAO1GNAI1MEN1KMT2A | |
| SCHEMBL8789042 | 0.63 | GNAO1 (0.37) | GNAI3GNAO1GNAI1MEN1KMT2A | |
| SCHEMBL7026105 | 0.61 | — | — | |
| SCHEMBL1081412 | 0.61 | GNAO1 (0.44) | GNAI3GNAO1GNAI1ALDH1A1CYP1A2 | |
| SCHEMBL293030 | 0.60 | GNAI3 (0.52) | GNAI3GNAO1GNAI1KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042279-B1 | N-ARYL-N'((1,4,5,6-TETRAHYDROPYRIMIDIN-2-YL) OR (4,5,6,7-TETRAHYDRO-1-H-1, 3-DIAZEPIN-2-YL)UREAS FOR INTESTINAL DISORDERS AND AS ANTIHYPERTENSIVES | McNeilab, Inc. (US) | 1985-11-13 | — | — | EP | disclosed |
| US-4466966-A | N-aryl-N'-(1,4,5,6-tetrahydropyrimidin-2-yl)ureas for intestinal disorders | MCNEILAB, INC. (US) | 1984-08-21 | — | — | US | disclosed |
| EP-0042279-A2 | N-aryl-N'((1,4,5,6-tetrahydropyrimidin-2-yl) or (4,5,6,7-tetrahydro-1-H-1, 3-diazepin-2-yl)ureas for intestinal disorders and as antihypertensives | McNeilab, Inc. (US) | 1981-12-23 | — | — | EP | disclosed |
| US-4285948-A | ADMINISTERING CARDIOTONIC AGENTS | MCNEILAB, INC. (US) | 1981-08-25 | — | — | US | disclosed |