Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11033286 | 0.82 | HTR4 (0.45) | MEN1KMT2AALDH1A1OPRM1 | |
| SCHEMBL11030825 | 0.82 | CHRM2 (0.51) | MEN1KMT2AGAAL3MBTL1CHRM2 | |
| SCHEMBL6577940 | 0.81 | CHRM1 (0.67) | MEN1KMT2AGAAL3MBTL1CHRM2 | |
| SCHEMBL4921218 | 0.78 | OPRM1 (0.66) | L3MBTL1ALDH1A1KDM4ETACR1OPRM1 | |
| SCHEMBL10268206 | 0.78 | MEN1 (0.66) | MEN1KMT2AGAAL3MBTL1CYP1A2 | |
| SCHEMBL2994414 | 0.78 | HTR2C (0.42) | CYP2C19CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13243414 | 0.77 | OPRL1 (0.45) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8060424 | 0.76 | OPRL1 (0.60) | OPRM1 | |
| SCHEMBL15642774 | 0.76 | NOD2 (0.50) | MEN1KMT2AL3MBTL1CHRM2CHRM4 | |
| SCHEMBL7582926 | 0.75 | OPRL1 (0.52) | CYP3A4TACR1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |