Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.68 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.68 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.65 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11437430 | 0.89 | ADRA1D (0.66) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL5984390 | 0.88 | OPRL1 (0.75) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL11031220 | 0.87 | ADRA1A (0.69) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| Hydrochloric Acid SCHEMBL11032271 | 0.86 | ADRA1A (0.80) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL11428029 | 0.85 | ADRA1A (0.83) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL11032634 | 0.84 | ADRA1D (0.71) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL11034160 | 0.84 | ADRA1D (0.66) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL11032558 | 0.84 | OPRM1 (0.70) | OPRL1ADRA1AADRA1DADRA1BADRB2 | |
| SCHEMBL23374511 | 0.83 | PLD1 (0.72) | OPRL1OPRM1OPRK1PLD1KDM4E | |
| Hydrochloric Acid SCHEMBL11033995 | 0.83 | ADRA1D (0.72) | OPRL1ADRA1AADRA1DADRA1BADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |