Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.62 |
| ▸ | PLD1 | Q13393 | 11/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | PLD2 | O14939 | 8/20 | 0.57 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032636 | 0.91 | PLD1 (0.64) | HSD11B1PLD1OPRM1PLD2OPRK1 | |
| SCHEMBL11221912 | 0.90 | HSD11B1 (0.50) | HSD11B1PLD1OPRM1PLD2TLR9 | |
| SCHEMBL11207325 | 0.89 | HSD11B1 (0.54) | HSD11B1PLD1OPRM1PLD2TLR9 | |
| SCHEMBL11206461 | 0.88 | HSD11B1 (0.64) | HSD11B1PLD1OPRM1PLD2 | |
| SCHEMBL10416280 | 0.87 | OPRM1 (0.63) | HSD11B1PLD1OPRM1PLD2OPRK1 | |
| SCHEMBL11033997 | 0.86 | PLD1 (0.53) | HSD11B1PLD1OPRM1PLD2OPRK1 | |
| SCHEMBL31422674 | 0.85 | OPRM1 (0.71) | PLD1OPRM1PLD2OPRK1OPRD1 | |
| Bromide SCHEMBL11033791 | 0.85 | PLD1 (0.60) | HSD11B1PLD1OPRM1PLD2OPRK1 | |
| SCHEMBL11030553 | 0.83 | HSD11B1 (0.73) | HSD11B1PLD1OPRM1PLD2OPRK1 | |
| Hydrochloric Acid SCHEMBL11033809 | 0.82 | HSD11B1 (0.72) | HSD11B1PLD1OPRM1PLD2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |