Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.60 |
| ▸ | PLD1 | Q13393 | 8/20 | 0.56 |
| ▸ | PLD2 | O14939 | 5/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11033800 | 0.87 | HSD11B1 (0.62) | OPRM1HSD11B1PLD1PLD2OPRD1 | |
| SCHEMBL11032636 | 0.83 | PLD1 (0.64) | OPRM1HSD11B1PLD1PLD2OPRD1 | |
| SCHEMBL31422674 | 0.83 | OPRM1 (0.71) | OPRM1PLD1PLD2OPRD1OPRK1 | |
| Bromide SCHEMBL11033791 | 0.83 | PLD1 (0.60) | OPRM1HSD11B1PLD1PLD2OPRD1 | |
| SCHEMBL10416342 | 0.82 | OPRM1 (0.68) | OPRM1HSD11B1OPRD1OPRK1OPRL1 | |
| SCHEMBL11030553 | 0.81 | HSD11B1 (0.73) | OPRM1HSD11B1PLD1PLD2OPRD1 | |
| Hydrochloric Acid SCHEMBL11033809 | 0.81 | HSD11B1 (0.72) | OPRM1HSD11B1PLD1PLD2OPRD1 | |
| SCHEMBL11033928 | 0.79 | HSD11B1 (0.56) | OPRM1HSD11B1PLD1PLD2OPRK1 | |
| SCHEMBL11033997 | 0.79 | PLD1 (0.53) | OPRM1HSD11B1PLD1PLD2OPRK1 | |
| SCHEMBL10694045 | 0.79 | PLD1 (0.54) | OPRM1HSD11B1PLD1PLD2OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902799-A | HYPOTENSIVE, HYPOLIPEMIC, ANTIANOXIC, SPASMOLYTIC, PLATELET AGGREGATION INHIBITING, ANTITHROMBOTIC, CALCIUM ANTAGONIZING, NEUROLEPTIC AGENTS | MAGGIONI-WINTHROP S.P.A. (IT) | 1990-02-20 | — | — | US | disclosed |